CONNECT IN THE MORNING
No more setting an alarm to remind you to take your levodopa pills every few hours! Just connect the Duopa pump in the morning — to get levodopa delivered continuously over 16 hours throughout the day.
BYPASSING THE STOMACH DELIVERS LEVODOPA WHERE YOU NEED IT
Duopa is delivered right into the intestine, so your levodopa can be absorbed quickly.
To prepare you for Duopa, a specialist makes a small hole (called a “stoma”) in the stomach wall and places a medication delivery port.* Afterwards, your doctor connects a portable pump to deliver levodopa continuously over 16 hours.
*A percutaneous endoscopic gastrostomy with jejunal tube (or “PEG-J”).
Your healthcare provider will talk to you about the stoma procedure. Before the stoma procedure, tell your healthcare provider if you ever had a surgery or problems with your stomach.
Talk to your healthcare provider about what you need to do to care for your stoma. After the procedure, you and your healthcare provider will need to regularly check the stoma for any signs of infection. Symptoms of infection may include: drainage, redness, swelling, pain, or feeling of warmth around the small hole in your stomach wall (stoma).
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YOUR DAILY ROUTINE
Because levodopa is delivered continuously over 16 hours, you won’t need to take your levodopa pills so often. Just connect the Duopa pump in the morning – to get levodopa delivered continuously throughout the day.
CONNECT IN THE MORNING
You’ll take a Duopa cassette out of the refrigerator and let it sit for 20 minutes at room temperature. Connect the pump to the cassette and then the stomach tube. Start the pump to get a morning dose. Your continuous dose will start automatically.
DISCONNECT AT NIGHT
After 16 hours, you’ll disconnect the pump. Flush the stomach tube with drinking water and discard the Duopa cassette. You can take a nighttime dose of oral carbidopa/levodopa pills if prescribed by your doctor.
Your doctor will decide if you need extra medicine during the day. If you feel like you’re “wearing off,” you can give yourself an extra dose through the pump. (Keep in mind that frequent extra doses may cause or worsen dyskinesia.)
Do not stop using DUOPA or change your dose unless you are told to do so by your healthcare provider. Tell your healthcare provider if you develop withdrawal symptoms such as fever, confusion, or severe muscle stiffness.
If you need to discontinue treatment or you and your doctor ever change your mind about Duopa, the procedure can be reversed. This lets you keep your options open for the future.
The medication delivery port can be completely removed by a specialist so the stoma heals. Do not stop using Duopa or change your dose unless you are told to do so by your doctor. Tell your doctor if you develop withdrawal symptoms such as fever, confusion, or severe muscle stiffness.
Talk to your healthcare provider about what you need to do to care for your stoma. After the procedure, you and your healthcare provider will need to regularly check the stoma for any signs of infection. Symptoms of infection may include: drainage, redness, swelling, pain, or feeling of warmth around the small hole in your stomach wall (stoma).
WHAT DO REAL PATIENTS THINK?
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DUOPA (carbidopa and levodopa) enteral suspension is a prescription medicine used for treatment of advanced Parkinson’s disease. DUOPA contains two medicines: carbidopa and levodopa.
What is the most important safety information I should know about DUOPA?
Your healthcare provider will talk to you about the stoma procedure. Before the stoma procedure, tell your healthcare provider if you ever had a surgery or problems with your stomach.
Talk to your healthcare provider about what you need to do to care for your stoma. After the procedure, you and your healthcare provider will need to regularly check the stoma for any signs of infection.
Do not take DUOPA if you currently take or have recently taken (within 2 weeks) a medication for depression called a non-selective monoamine oxidase (MAO) inhibitor. Ask your healthcare provider or pharmacist if you are not sure if you take an MAO inhibitor.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using DUOPA with certain other medicines, including medications for high blood pressure, MAO inhibitors, antipsychotics, metoclopramide, isoniazid, and iron or vitamin supplements, may cause serious side effects. High-protein foods may affect how DUOPA works. Tell your healthcare provider if you change your diet.
DUOPA may cause serious side effects. Talk to your doctor before starting DUOPA and while on DUOPA if you have had or have any of these:
Do not stop using DUOPA or change your dose unless you are told to do so by your healthcare provider. Tell your healthcare provider if you develop withdrawal symptoms such as fever, confusion, or severe muscle stiffness.
The most common side effects of DUOPA include: complications of tubing placement procedure, swelling of legs and feet, nausea, high blood pressure (hypertension), depression, and mouth and throat pain.
Please see the full Prescribing Information including Medication Guide for additional information about DUOPA. Talk to your healthcare provider if you have questions.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.
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